Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
نویسندگان
چکیده
منابع مشابه
Photodynamic Therapy (PDT): PDT Mechanisms
Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how t...
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Despite its more than 100-year history in experimental and clinical use, photodynamic therapy (PDT) is only starting to be appreciated for its full potential. PDT combines a photosensitizer (PS) and light in the presence of oxygen to treat cancer and other disorders. This manuscript reviews molecular mechanisms that have been evaluated over the past years for the effects of PDT at the cellular ...
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In vivo biological application of upconversion nanoparticles (UCNPs) prefers excitation of 700-850 nm, instead of 980 nm, due to the absorption of water. Recently approach in constructing robust Nd doped UCNPs subject to 808 nm excitation relies on a thick Nd sensitized shell. However, for the very 10 important and popular Förster resonance energy transfer (FRET)-based applications, such as pho...
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Molecular imaging is a novel field in cancer research combining various in vivo imaging modalities with molecular biology. Different techniques such as magnetic resonance tomography (MRI), positron emission tomography (PET), optical imaging methods (bioluminescence, fluorescence), or combination of these are used in basic research as well as in patients in different tumor entities. In hepatobla...
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Photodynamic therapy (PDT) is a promising modern approach for cancer therapy with low normal tissue toxicity. This study was focused on a vascular-targeting Chlorine E6 mediated PDT. A new angiographic imaging approach known as M-mode-like optical coherence angiography (MML-OCA) was able to sensitively detect PDT-induced microvascular alterations in the mouse ear tumour model CT26. Histological...
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ژورنال
عنوان ژورنال: Chemical Reviews
سال: 2010
ISSN: 0009-2665,1520-6890
DOI: 10.1021/cr900300p